What are the characteristics of glass tube pre filling and sealing filling machine?

1、 Extremely sterile design, meeting high cleanliness requirements 1 Full process aseptic control: The core working area of the equipment (filling, sealing, etc.) usually adopts isolation technology (such as RABS isolation device, glove box) or laminar flow protection to maintain a hundred level clean environment and avoid contact between the product and external pollution sources; Some high-end equipment is equipped with online sterilization (SIP) and online cleaning (CIP) functions, which can perform in-situ sterilization/cleaning of key components such as pipelines, filling heads, and chambers, completely eliminating cross contamination. two Aseptic docking and sealing: achieve aseptic docking with upstream container supply systems (such as sterile pre filled syringe feeding) and downstream sealing systems (such as plug pressing and capping) to reduce the risk of contamination during transportation; Configure specialized sealing components for different container types to ensure the sealing of the filled container and prevent microbial invasion. 2、 High precision filling ensures product consistency Precision metering technology: High precision metering pumps (such as ceramic pumps, plunger pumps) or time pressure filling systems driven by servo motors can achieve precise filling of small dose (such as 0.1ml) to medium dose (such as 20ml) products. The filling accuracy error is usually controlled within ± 1%, and some equipment can reach ± 0.5%, meeting the strict requirements of pharmaceutical products for dose uniformity. two Strong stability: The transmission system adopts precision components, combined with closed-loop control technology, to reduce vibration and errors during equipment operation, ensure consistent filling accuracy of products within batches, and avoid quality problems caused by dosage deviation. 3、 High degree of automation integration, improving production efficiency 1 Continuous and integrated operation: It can seamlessly connect with pre - and post process equipment such as bottle washing machines, sterilization machines, freeze-drying machines, labeling machines, etc., forming an automated production line of "container processing filling sealing testing packaging", achieving continuous operation and greatly improving unit time production capacity (some high-speed models can reach 600pieces/hour). two Intelligent control and operation: equipped with PLC control system and human-computer interaction interface, supporting parameter preset, formula storage (can store filling parameters of multiple varieties of products), fault alarm and other functions, easy to operate; Some equipment is equipped with a visual inspection system, which can detect in real-time issues such as filling volume deviation, container damage, and poor sealing, achieving automatic removal of non-conforming products and reducing manual inspection costs. 4、 Flexible adaptability to meet the needs of multiple scenarios Multi container compatibility: By replacing modular components such as filling heads and positioning components, it can adapt to different specifications of pre filled syringes, penicillin bottles, cartridge bottles, and other containers, as well as filling needs of different capacities, without the need for overall equipment replacement, reducing enterprise equipment investment costs. two Multi product adaptation: special filling components (such as low shear filling head, anti foam device) can be configured for materials with different characteristics, such as liquid, suspension, high viscosity preparations (such as biological protein preparations, gel products), to avoid the destruction of material characteristics (such as protein denaturation, suspension stratification), and to ensure the efficacy and stability of the product. 5、 Strong compliance and adaptability to industry regulatory requirements Material and design compliance: Components in contact with materials are made of inert materials that comply with GMP standards, such as 316L stainless steel PTFE）， Strong corrosion resistance and does not react with materials; The equipment structure design has no dead corners, is easy to disassemble, and is convenient for cleaning and verification, meeting the basic requirements of the pharmaceutical industry for equipment compliance. two Traceability and Audit Traceability: Supports data recording and traceability functions, which can automatically record key parameters during the production process (such as filling volume, sterilization temperature, production time), equipment operation status, operator information, etc., forming electronic batch records, facilitating regulatory audits and enterprise quality traceability, and meeting the strict regulatory requirements of the pharmaceutical industry. 6、 Product protection is in place to reduce losses Low damage filling: For sensitive materials such as biologics, low shear filling technology and soft material conveying pipelines are used to reduce mechanical damage during the filling process and avoid loss of active ingredients; Some equipment is equipped with nitrogen protection devices, which can be filled with nitrogen to replace the air inside the container during the filling process, slowing down the oxidation and deterioration of materials. two Reduce material waste: By adopting precise filling control and residual liquid recovery design, the residue of materials in pipelines and filling heads can be reduced, especially for high-value pharmaceutical materials (such as biological vaccines), which can significantly reduce production costs and material losses.